ExCyte™
Extracellular Vesicle
Until recently, exosomes were thought to simply be a cellular component responsible for offloading cellular waste. In the past ten years, cellular biologists have come to realize that exosomes, a type of extracellular vesicle, are in fact of enormous biological interest. Exosome release is a regulated process and these vesicles play a role in cell signal transduction. They may also be involved in tissue regeneration. Now, exosomes are considered an exciting field of cellular biology with possible real-world clinical applications.
You can rely on our highly purified and highly concentrated product known as ExCyte™.
Adult stem cells do not become engrafted. They do not become other types of cells. They are designed to heal, and they heal through peregrine activity. Once they find inflamed cells, they secrete many factors, “The secretome,” including exosomes. They carry proteins in microRNA, et cetera. Through the cell membrane, and have the ability to turn on the healing and regenerative capacity of the damaged or inflamed cell.
Human hematopoietic stem cells and mesenchymal stem cells are characterized by their self-renewing capacity and ability to differentiate into chondrocytes, adipocytes, and osteocytes. This makes them attractive candidates for use in tissue engineering and regenerative medicine.
Following cell transplantation, relatively few transplanted cells live or localize to the site of interest. in vivo. Therefore, effective cell therapies may incorporate secreted cell factors such as exosomes, which can be secreted upon fusion with the plasma membrane.
According to publications available today :
- Exosomes contain protein and RNA
- They may be a source of paracrine signals from stem cells
- Exosomal protein and RNA may be modified to desired specifications
- Exosomes are stable products and may bypass many of the limitations of cultured cells
- Exosomes derived from adipose-graft or pre-adipocytes may promote cell proliferation and skin repair in in-vitro and in vivo studies
All cells must be screened negative for HIV, HBV, HCV, CMV(IgM), Syphilis, WNV, HTLV I/II Ab, Chagas, and Lyme Disease.
| Weight | 1 lbs |
|---|---|
| Size | 1cc (125 Billion), 2cc (225 Billion), 4cc (625 Billion) |
| Manufacturer | Novoxa |
| U/M | 1cc (125 Billion), 2cc (225 Billion), 4cc (625 Billion) |
| Storage | Sterile Vial |
| Shipping Temp/Condition | Frozen ( -81 celcius) |
| Storage Temp | (-80 to -90 celcius) |
| Media Expiry, 4C | N/A |
| Media Expiry, -20C | N/A |
| Preservative | DPBS ( Saline ) |
